Papel del coactivador PGC-1α en el balance energético. Importancia en la producción de bovinos de engorda.

Abstract

The importance of dietary fat in the expression of multiple genes is clear, in the case of beef cattle, fat in the form of fatty acids (saturated or unsaturated), vitamin A (mainly retinoic acid), or carotenoids (β-carotene, lutein, licopen and their metabolites), is obtained constantly from the dietary feed or from pasture. This review tries to summarize the advances in the study of some of the transcription factors and their co-regulators, specifically coactivator PGC-1, which has been observed to affect the transcription of genes involved in energy homeostasis. The capacity of dietary lipids or their metabolic products, to influence on PGC-1α, due in part to the presence of an element of answer to PPAR in its genic promoter, which appears to be conserved in different species of mammals including bovines. It might be important to find nutrients or other types of compounds, that could act as ligands of the factors of transcription of specific genes, that control metabolic processes such as gluconeogenesis and lipolysis in rumiants so in a near future they would contribute to improve the production in the specie.