FR 46. Seminiferous tubule wide diminished in testicles of turkeys (Meleagris gallopavo) fed furazolidone in their diets. Preliminar findings
The purpose of this work was to determine the effects of Furazolidone (Fz) on the seminiferous tubules of testicles of turkeys treated with the drug since the first day of life for long periods. Eighteen hybrid males were split into: Treated: fed Fz 0.04 % w/w during a) 36 weeks (Ta); b) 44 weeks (Tb); and Control (untreated) c) 36 weeks (Ca). and 44 weeks (Cb). At the end of the experimental periods, the birds were sacrificed and both testis extracted, fixed and processed according to conventional histological procedure and stained with eosin-hematoxilin. Microscopic findings of the germinal line, Sertoli and Leydig cells were verified. In a microscope with digitalised image analyzer, the average diameter and the area of the seminiferous tubules were measured. Data were analysed using a mixed model nested design. Numerous lipidic vacuoles were seen among the spermatocytes I and spermatids and also many picnotic cells and macrophages. The seminiferous tubule diameters were similar to Controls (non significant), but the area was inferior in both treated groups (P<.05). It is concluded that Fz affected testis by the diminution of the tubule area and the germinal line, when given to turkeys at subtherapeutical doses during long periods.