Use of intrauterine ozone therapy to treat subclinical endometritis in repeating service cows
Subclinical endometritis (SS) is endometrial inflammation usually determined by cytology, in the absence of purulent material in the vagina. In animals without signs of clinical endometritis, the subclinical form of the disease is diagnosed by measuring the proportion of neutrophils present in samples collected by washing the uterine lumen or using a cytobrush. Uterine pathologies play a primary role in reducing reproductive efficiency, with delays in the return of postpartum ovarian activity, increased calving-first service and calving-conception intervals, decreased pregnancy rates from 56% to 30 %, increased number of services per conception and higher culling rates. At present, the different therapeutic treatments such as ozone therapy are focused on improving the intrauterine environment for the survival of the embryo, arousing interest in using alternative therapies to antibiotics applied intrauterinely against uterine infectious processes. The objective of this research was to evaluate the effect of ozone therapy in the treatment of subclinical endometritis in repeating cows.
Cengiz, M., Altun, S., Comakli, S., Cengiz, S., Hayirli, A. (2021). A reliable method using the cytobrush for diagnosis of subclinical endometritis in dairy cattle during the late lactational period. Animal Reproduction Science, 235, 106891. https://doi.org/10.1016/j.anireprosci.2021.106891.
Elvis, A. M., Ekta, J. S. (2011). Ozone therapy: A clinical review. Journal of natural science, biology, and medicine, 2(1), 66. https://doi.org/10.4103/0976-9668.82319.
Kasimanickam, R., Duffield, T. F., Foster, R. A., Gartley, C. J., Leslie, K. E., Walton, J. S., Johnson, W. H. (2004). Endometrial cytology and ultrasonography for the detection of subclinical endometritis in postpartum dairy cows. Theriogenology, 62(1-2), 9-23. https://doi.org/10.1016/j.theriogenology.2003.03.001.
Leitman, N. R., Busch, D. C., Mallory, D. A., Wilson, D. J., Ellersieck, M. R., Smith, M. F., Patterson, D. J. (2009). Comparison of long-term CIDR-based protocols to synchronize estrus in beef heifers. Animal Reproduction Science, 114(4), 345-355. https://doi.org/10.1016/j.anireprosci.2008.10.014.
Lima, F. S. D. (2020). Recent advances and future directions for uterine diseases diagnosis, pathogenesis, and management in dairy cows. Animal Reproduction, 17(3):e20200063. https://doi.org/10.1590/1984-3143-AR2020-0063.
Lopdell, T., Berg, M. C., Green, M. P., & Back, P. J. (2011). Effect of sub-clinical uterine infection on plasma amino acid concentrations in early lactation dairy cows. In Proceedings of the New Zealand Society of Animal Production (Vol. 71, pp. 291-295). New Zealand Society of Animal Production.
da Luz, N. F. V. (2013). Estudo do Efeito da Aplicação Intrauterina de Ozono Sobre a Taxa de Gestação, Após Inseminação Artificial, em Vacas Repetidoras de Raça Frísia Holstein (Doctoral dissertation, Universidade de Lisboa (Portugal)).
Madoz, L. V., Giuliodori, M. J., Jaureguiberry, M., Plöntzke, J., Drillich, M., de la Sota, R. L. (2013). The relationship between endometrial cytology during estrous cycle and cutoff points for the diagnosis of subclinical endometritis in grazing dairy cows. Journal of dairy science, 96(7), 4333-4339. https://doi.org/10.3168/jds.2012-6269.
Polat, B., Cengiz, M., Cannazik, O., Colak, A., Oruc, E., Altun, S., Salar, S., Bastan, A. (2015). Endometrial echotexture variables in postpartum cows with subclinical endometritis. Animal Reproduction Science, 155, 50-55. https://doi.org/10.1016/j.anireprosci.2015.01.015
Pothmann, H., Prunner, I., Wagener, K., Jaureguiberry, M., de la Sota, R. L., Erber, R., Aurich, C., Ehling-Schulz M., Drillich, M. (2015). The prevalence of subclinical endometritis and intrauterine infections in repeat breeder cows. Theriogenology, 83(8), 1249-1253. https://doi.org/10.1016/j.theriogenology.2015.01.013.
Ricci, A., Bonizzi, G., Sarasso, G., Gallo, S., Dondo, A., Zoppi, S., & Vincenti, L. (2017). Subclinical endometritis in beef cattle in early and late postpartum: Cytology, bacteriology, haptoglobin and test strip efficiency to evaluate the evolution of the disease. Theriogenology, 94, 86-93. https://doi.org/10.1016/j.theriogenology.2017.02.006.
Samardžija, M. (2014). Effect of intrauterine ozone treatment in cows with repeat-breeding syndrome after bacteriological testing of uterine swabs. In Proceedings of the 18th Annual Conference of the European Society for Domestic Animal Reproduction (ESDAR), p. 93.
Sheldon, I. M., Lewis, G. S., LeBlanc, S., Gilbert, R. O. (2006). Defining postpartum uterine disease in cattle. Theriogenology, 65(8), 1516-1530. https://doi.org/10.1016/j.theriogenology.2005.08.021.
Yáñez, U., Herradón, P. G., Becerra, J. J., Peña, A. I., & Quintela, L. A. (2022). Relationship between postpartum metabolic status and subclinical endometritis in dairy cattle. Animals, 12(3), 242. https://doi.org/10.3390/ani12030242.
Zobel, R., Tkalčić, S., Štoković, I., Pipal, I., Buić, V. (2012). Efficacy of ozone as a novel treatment option for urovagina in dairy cows. Reproduction in domestic animals, 47(2), 293-298. https://doi.org/10.1111/j.1439-0531.2011.01857.x.
Zobel, R. (2013). Endometritis in Simmental cows: Incidence, causes, and therapy options. Turkish Journal of Veterinary & Animal Sciences, 37(2), 134-140. https://doi.org/10.3906/vet-1105-2.
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