Localization of progesterone receptor isoform A in the uterus of non- pregnant sows and maternal placenta during early gestation

  • María del Carmen Viglierchio Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias. calle 5 esq. 116. General Pico - La Pampa
  • Sara Inés Williams Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias
  • Mónica Graciela García Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias
  • Daniel Vicente Lacolla Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias
  • Vanina Nerea Murcia Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias
  • Graciela Noemí Yaful Uiversidad Nacional de Río Negro. Veterinaria. UNLPam. Facultad de Ciencias Veterinarias

Abstract

The progesterone (P4) produced by the corpus luteum, plays a vital role in the preparation, reception of embryos and maintenance of pregnancy. Its effects are mediated by the interaction with its specific intracellular receptors. The aim of this study was to investigate the localization of the progesterone receptor isoform A (PRA) in histological endometrial samples from crossbred pregnant and non-pregnant sows, and the relationship with plasma P4 levels. Nonpregnant sows in the follicular phase and pregnant sows at days 5, 17 and 35 of gestation (n=16) were used. The localization of the PRA was determined by immunohistochemistry with monoclonal antibodies. In the endometrium of nonpregnant and pregnant sows at day 5 of gestation PRA expression was observed in the nuclei of epithelium cells, uterine glands, stroma and myometrium. While on day 17 of gestation PRA expression was found in glands, stroma and myometrium, and on day 35 the expression was observed in the stroma and myometrium. An increase in serum P4 concentrations was found on day 17 of gestation. The localization and variations in the score for PRA in different cell types may reflect a cell-specific influence of progesterone, which might be explained by increasing P4 levels during the «window of implantation»

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Author Biographies

María del Carmen Viglierchio, Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias. calle 5 esq. 116. General Pico - La Pampa
Profesor Adjunto Química Biológica. Ciencias Básicas
Sara Inés Williams, Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias
Profesora Adjunta Zootecnia I y Reproducción Animal. Producción Animal
Mónica Graciela García, Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias
Ayudante de 1° Histología I y II. Ciencias Básicas
Daniel Vicente Lacolla, Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias
Profesor Adjunto Histología I y II. Ciencias Básicas
Vanina Nerea Murcia, Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias
Estudiante
Graciela Noemí Yaful, Uiversidad Nacional de Río Negro. Veterinaria. UNLPam. Facultad de Ciencias Veterinarias
Profesor Adjunto (UNRN). Jefe de Trabajos Prácticos Obstetricia y Fisiopatología de la Reproducción (UNLPam).
Published
2014-05-15
How to Cite
Viglierchio, María del Carmen, Sara Inés Williams, Mónica Graciela García, Daniel Vicente Lacolla, Vanina Nerea Murcia, and Graciela Noemí Yaful. 2014. “Localization of Progesterone Receptor Isoform A in the Uterus of Non- Pregnant Sows and Maternal Placenta During Early Gestation”. Archivos Latinoamericanos De Producción Animal 22 (3-4). https://ojs.alpa.uy/index.php/ojs_files/article/view/2353.
Section
Original paper